A Prospective Quality Improvement Program to Reduce Prolonged Postoperative Antibiotic Prophylaxis in Ethiopia

Introduction: Although postoperative antibiotic prophylaxis has not been shown to prevent surgical site infections, prolonged antibiotic administration is common in low- and middle-income countries. We developed a quality improvement program to reduce unnecessary postoperative antibiotics through hospital-specific guide-line development and the use of a brief, multidisciplinary discussion of antibiotic indication, choice, and duration during clinical rounds. We assessed reduction in the number of patients receiving ‡24 h of antibiotic prophylaxis after clean and clean-contaminated surgery.

Methods: We piloted the program at a referral hospital in Ethiopia from February to September 2023. After a 6-week baseline assessment, multidisciplinary teams adapted international guidelines for surgical prophylaxis to local disease burden, medication availability, and cost restrictions; stakeholders from surgical departments provided feedback. Surgical teams implemented a “timeout” during rounds to apply these guidelines to patient care; compliance with the timeout and antibiotic administration was assessed throughout the study period.

Results: We collected data from 636 patients; 159 (25%) in the baseline period and 477 (75%) in the intervention period. The percentage of patients receiving ‡24 h of antibiotic prophylaxis after surgery decreased from 50.9%in the baseline period to 40.9% in the intervention period (p =0.027) and was associated with a 0.5 day reduction in postoperative length of stay (p =0.047).

Discussion: This antibiotic stewardship pilot program reduced postoperative antibiotic prophylaxis in a resource-constrained setting in Sub-Saharan Africa and was associated with shorter length of stay. This program has the potential to reduce unnecessary antibiotic use in this population.

Keywords: antibiotic prophylaxis; antimicrobial resistance; surgical site infection